Pharmacological screening of novel indolo [2,3-b] quinoxaline derivatives
نویسنده
چکیده
Condensation of o-phenylenediamine with isatine in refluxing glacial acetic acid gives indolo[2,3-b] quinoxaline. This moiety further condensed with n’-(n-Halo aloxy)-3,4-dihydro carbostyril in refluxing acetonitrile using NaI,K2CO3 and TBAB as catalyst gave us desire product. Series of all six analogs are taken for their antibacterial and antipsychotic activity. The entire tested compound showed slight antibacterial as well as antipsychotic activity. This slight antimicrobial activity is due to presence of indolo[2,3-b] quinoxaline, and moderate antipsychotic activity due to the structural resemblance with the antipsychotic drug Aripiperazole.
منابع مشابه
Palladium catalyzed synthesis and physical properties of indolo[2,3-b]quinoxalines.
A series of indolo[2,3-b]quinoxaline derivatives were efficiently synthesized from 2,3-dibromoquinoxaline by two pathways. A one-pot approach using Pd-catalyzed two-fold C-N coupling and C-H activation reactions gave indolo[2,3-b]quinoxaline derivatives in good yields, but with limited substrate scope. In addition, a two-step approach to indolo[2,3-b]quinoxalines was developed which is based on...
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